izv. prof. dr. sc. Milena Jadrijević-Mladar-Takač

Profile

Dr. sc. Milena Jadrijević-Mladar Takač is Associate Professor at the Department of Medicinal Chemistry. She is is a leader and a teacher of the following courses which are performed in Croatian and English languages at the graduate level, i.e., Medicinal Chemistry and Biochemistry of Drugs, and at the postgraduate level of Doctoral studies 'Pharmaceutical and Biochemical Sciences', the course 'Drugs as Enzyme Inhibitors, as well. Dr. Jadrijevic's research interest are biologically active molecules and towards the biological target directed drug design, a study of structural, physicochemical and ADMET properties, the use of molecular descriptors and drug-likeness parameters with the drugs of known pharmacological effects, and the other properties which are responsible for pharmacological effects as well as to the adverse drug effects of medicines which are in clinical use. The research is specifically directed toward enzyme inhibitor drugs, with an emphasis on protein tyrosine kinase and histone deacetylase inhibitors.

Education:

• 1994 PhD in Natural Sciences - Chemical sciences, obtained from Faculty of Pharmacy and Biochemistry, University of Zagreb
• 1986 Postgraduate Studies in Chemistry - Analytical chemistry, Faculty of Science, University of Zagreb, Title – Master of Science in chemistry
• 1981 Faculty of Pharmacy and Biochemistry; University of Zagreb, Graduate study of Pharmacy, academic title: Master of Pharmacy

Work experience:

• 1981 - Department of Medicinal Chemistry, Faculty of Pharmacy and Biochemistry, University of Zagreb,
• 2005 – 2007 Head of the Centre for Applied Pharmacy, Faculty of Pharmacy and Biochemistry, University of Zagreb,
• 2003 – 2006 Vice Dean for Education, Faculty of Pharmacy and Biochemistry, University of Zagreb,
• 2003 – 2006 Contact person for international cooperation and ECTS, Faculty of Pharmacy and Biochemistry, University of Zagreb,
• 2008 – 2012 Member of the HALMED Committe for medicines, Croatia

Visiting positions:

• 1994 Faculty of Pharmacy, University of Padova, Padova, Italy
• 2002 Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia
• More than 50 international stays in the foreign institutions as a leader of the CRO PharmDiab Project (part of the WHO project EuroPharmForum Diabetes Care and the National Programme for the Protection of Deabetes mellitus) or as a coordinator of international projects (EC TEMPUS JEP-18028-2003 'New Pharmacy Curricula - Development and Implementation), and as a member of the international working groups (EUFEPS ExCo, EMA ENCePP WG 1), European Cooperative Medicines Development Course (CEMDC), etc.

Projects:

• 2014 BM2.3, 'The study of the features of protein tyrosine kinase and histon deacetylase inhibitors in antitumor therapy', Biomedicine, granted by the University of Zagreb, project leader;
• 2013 KFPI 2, 1.1.2.5, 'The study of the features of protein tyrosine kinase inhibitors in antitumor therapy', Biomedicine, granted by University of Zagreb, project leader;
• 2013- 2014 'Modelling of molecules and materials by methods of mathematical and computational chemistry', No. 006-0982929-2940, granted by the Ministry of Science, Education and Sports of the Republic of Croatia, project leader;
• 2007. - 2012. 'Modelling of molecules and materials by methods of mathematical and computational chemistry', No. 098- and 177-0982929-2940, project leader Prof. Ante Graovac), granted by the Ministry of Science, Education and Sports of the Republic of Croatia, collaborator;
• 2004 – 2007 'New Pharmacy Curricula - Development and Implementation', TEMPUS JEP-18028-2003, granted by the European Commission, coordinator in partner country;
• 2002 – 2006 'Drug substances and excipients - synthesis, characterization and activity’, project no. 0006543 (project leader: Prof. Branka Zorc),, granted by the Ministry of Science, Education and Sports of the Republic of Croatia, collaborator;
• 1996 – 2002 'Biotics and xenobiotics – preparation, characterization and activity', project no. 0006543 (project leaders: Prof. Ivan Butula and Prof. Branka Zorc), granted by the Ministry of Science and Technology of the Republic of Croatia, collaborator;
• 1997 – 2002 'CRO PharmDiab', a part of the WHO EuroPharm Forum Project Diabetes Care and the National Programme for the Protection of Diabetes Mellitus, project leader;
• 199 – 1996 'New generation of drugs: substances and therapeutic systems', Projected no. 3-04-321 (project leader Prof. Ivan Jalšenjak), granted by the Ministry of Science and Technology of the Republic of Croatia, collaborator;
• 1988 – 1991 'Synthesis, biological activity and metabolism of known medicinal substances', project no. 2.03.01.00.22 (project leader: Prof. Ivan Butula), granted by the Ministry of Science and Technoogy of the Republic of cRoatia, collaborator;
• 1985 -1988 ontinuing education for primary health care’, Croatian – Japanese IT project, School of Public Health 'Andrija Štampar’ (project leader: Prof. Želimir Jakšić), sponsored by the Japan International Cooperation Agency; coordinator of the FBF Active unit:
• 1981- 1986 Project II-21 RZZR (project leader: Prof. Marija Movrin), granted by the Ministry of Science and of the Republic of cRoatia, collaborator;

Awards and honours:

• 1991 Societas Pharmacopolarum Croatiae pro singularibus meritis in provehenda arte pharmaceutica hoc diploma;
• 1996 Honorary membership of the Texas Pharmaceutical Society and Golf Coast Pharmaceutical Association;
• 2010 Dr. Julius Domac Medal, Croatian Pharmaceutical Society award in recognition of achievements in professional, scientific and societal work in pharmacy that significantly raised the reputation of pharmaceutical profession;
• 2011 Faculty of Pharmacy and Biochemistry acknowledgement for personal contribution to the activity, development and promotion of the reputation of Faculty.

Memberships in professional associations/societies:

• 1981 - Croatian Pharmaceutical Society (CPhS);
• 1997 - Croatian Chamber of Pharmacists (CCP);
• 1996 - International Pharmaceutical Federation (FIP);
• 2006 - European Federation of Pharmaceutical Sciences (EUFEPS), member of EUFEPS Council (2006 -); EUFEPS member of Executive Committee (2010-2016);
• 2007 - ISPOR CROATIA, Croatian Society for Pharmacoeconomics and Outcomes research;
• 2008 – EMA ENCePP, Working Group 1;
• 2008 - 2012 - HALMED Committee for Medicinal Products;
• 2013 - HALMED Committee for Medicinal Products, external associate;
• 1996 - European Forum of Pharmaceutical Association (EuroPharm Forum / WHOEuro); 1998 - Section for General and Applied Spectroscopy.

Other:

Memberships in scientific and organization committees of national and international conferences:

• The Program Committee of the First Croatian Congress on Pharmacy, Zagreb, HR, 5 - 7 /06 1996 ;
• The Organizing Committee of the '10th Annual Meeting of EuroPharm Forum', Dubrovnik, HR, 11- 14/ 10/2001;
• The Scientific Committee of the Second Croatian Congress of Pharmacy, Cavtat, HR, 31/05 – 3/06/2001;
• The Scientific Committee of the Third Croatian Congress of Pharmacy, Cavtat, HR, 27 – 30/04/2005;
• The Organizing Committee of the Ixth Pharmaceutical Conference, Pharmacists Association of Zagreb region, Opatija, HR, 25 – 27/06/2006.;
• European Publicity Committee, PSWC 2007, Pharmaceutical Sciences World Congress, Optimising Drug Therapy - An imperative for world health, Amsterdam, NL, 22 – 25/04/2007;
• The Planning Team, International Scientific Board and Organizing Committee, of the EUFEPS/ CPhS Conference in Zagreb 'Networking in Pharmaceutical Sciences, Zagreb, HR, 27/02/2009;
• International Scientific Board, 3rd BBBB International Conference on Pharmaceutical Sciences, TUFTAD & EUFEPS, Antalya, TR, 26 - 28/10/2009;
• PharmSciFair Organizing Committee, 3rd Pharm SciFair 2011 'Pharmaceutical Sciences for the Future of Medicines', Prague, Czech Republic, 13 -17/06/2011;
• PharmSciFair Programme Coordination, 3rd Pharm SciFair 2011 'Pharmaceutical Sciences for the Future of Medicines', Prague, CZ, 13 -17/06/2011;
• International Advisory Committee, Helsinki Drug Research 2011 'Tools for ADMET and Pharmaceutical Nanotechnology', Helsinki, FI, 18 – 20/09/2011;
• International Scientific Advisory Board, EUFEPS/ CPhS Zagreb International Conference on Pharmaceutical Sciences, Networkin and Pharmaceutical Sciences, Zagreb, HR, 27/02/2009;
• Scientific Committee, International Conference, Contemporary developments in Pharmacy, Pristhina, HP, 22-23/09/2012;
• International Scientific Advisory Board, Zagreb 2nd International Conference on Pharmaceutical Sciences, Sharing a vision - Towards better and safe medicines, Zagreb, HR, 25-26/10/2013;
• Scientific Committee, 2nd International Conference on Contemporary developments in Pharmacy, Priizren HP, 19-21/09/2014;
• Founder of the Center for Applied Pharmacy at the Faculty of Pharmacy and Biochemistry, and the International Conference on Pharmaceutical Sciences (ZICPS), which is held every four years in Zagreb
• 2004 – 2007 Coordinator in the partner country of the international EC TEMPUS project, TEMPUS JEP-18028-2003 'New Pharmacy Curricula - Development and Implementation',
• 2010 – 2016 Member of the Executive Committee of the European Federation for Pharmaceutical Sciences (EUFEPS).
• 2008 – 2012 EMA ENCePP WG1, member